Catalog Number - 85118-10P

The 85118‑10P Cogent RP C18 ABX™ UHPLC Column is engineered for robust, high‑resolution separations under extreme mobile phase conditions, delivering stable performance across a wide pH range (2–12).

Featuring a bulky end‑capped C18 bonded phase on high‑purity silica, this column minimizes secondary interactions and improves peak shape for acidic, basic, and neutral analytes, especially those with very high or very low pKa values.

✅ Ideal as a USP L1 alternate for methods involving strong acids or bases

100 mm Length – Increased Resolution for Analytical Methods

• Higher resolving power than 50 mm columns

• Improved separation of closely related compounds

• Increased peak capacity for complex mixtures

• Ideal for method development and refinement workflows

✅ Selected when higher resolution is required beyond fast screening methods

4.6 mm ID – Standard Analytical Platform

• Compatible with standard UHPLC systems

• Ideal for:

  • method development

  • routine QC and analytical workflows

Typical Flow Rate Range

• ~0.8–1.5 mL/min

✅ Provides robust, reproducible analytical performance

1.8 µm Particle – Maximum Efficiency & Performance

• Delivers ultra‑high efficiency and sharper peaks

• Greater peak capacity vs 3 µm columns

• Improves:

  • resolution in existing methods

  • speed while maintaining separation quality

✅ Ideal for:

• Reducing run times without sacrificing resolution

• Enhancing separation performance

⚠️ Higher backpressure → UHPLC system required

Wide pH Stability (pH 2–12) – Extreme Method Flexibility

• Designed for acidic and basic mobile phases

• Enables separation of:

  • Strong acids

  • Strong bases

  • Challenging polar compounds

✅ Extends method capability beyond standard C18 limitations

Why Choose RP C18 ABX™ Columns

Extreme pH Ruggedness

• Stable across full pH spectrum (2–12)

• Ideal for challenging and aggressive analytical conditions

Improved Peak Shape for Acids & Bases

• Advanced end‑capping minimizes secondary interactions

• Improves reproducibility and accuracy

Higher Throughput & Efficiency

• Faster runs reduce solvent usage and cost

• Increased instrument throughput and productivity

✅ Ideal for analytical labs focused on efficiency and performance

System & Sample Considerations

• ⚠️ Requires UHPLC system capable of high pressure operation

• Recommended sample preparation:

  • 👉 Use 0.2 µm syringe filters for proper sample preparation before injection

✅ Helps:

• Prevent column plugging

• Maintain performance and column lifetime

Typical Applications

• UHPLC and HPLC analysis

• Acidic and basic compound separations

• Pharmaceutical method development

• Stability‑indicating methods

• Hydrophobic and neutral compound analysis

• Complex mixture resolution under extreme pH

Important Usage Notes

• Designed for UHPLC (high‑pressure) systems

• Suitable for extreme pH mobile phases (pH 2–12)

• Ideal for method development and optimization workflows

• Monitor system pressure to ensure safe operation